Effect of warfarin on chronic idiopathic urticaria.

Sir, Urticarias unresponsive to antihistamines are frustrating for both physicians and patients. In severe cases, steroids or cyclosporine may be needed.[1] This retrospective observation highlights the potential of warfarin in managing chronic idiopathic urticaria (CIU). halobetasol ointment (P = 0.005), clobetasol ointment and halobetasol ointment (P = 0.015) and halobetasol cream and halobetasol ointment (P = 0.035). Maximum wheal suppression at the end of 3 h was seen with halobetosol ointment followed by halobetosol cream whereas wheal suppression was least with clobetasol cream. At 24 h, the difference in wheal suppression between clobetasol ointment and halobetasol cream and halobetasol ointment were not statistically significant. However, there was a statistically significant difference in wheal suppression between clobetasol cream and clobetasol ointment (P = 0.001), clobetasol cream and halobetasol cream (P = 0.002) and clobetasol cream and halobetasol ointment (P = 0.000), which was statistically significant. At the end of 24 h, there was no statistically significant difference in wheal suppression between halobetosol ointment, cream and clobetasol ointment, but clobetasol cream was the least effective.